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Date Published: 11/05/2021
Abstract Views: 118
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DOI: https://doi.org/10.60117/vjmap.v36i3.143
Issue
Vol. 36 No. 3 (2021)
Section
Research Articles
How to Cite
Nguyễn, T. T., Phạm, Q. B., Phạm, T. V. A., & Đinh, T. T. H. (2021). Evaluation of protetive effect of “Kien ty chi thong HV” remedy on gastric-duodenal ulcer in experiment. Viet Nam Journal of Traditional Medicine and Pharmacy, 36(3), 4-10. https://doi.org/10.60117/vjmap.v36i3.143

Evaluation of protetive effect of “Kien ty chi thong HV” remedy on gastric-duodenal ulcer in experiment

Thanh Trung Nguyễn, Quốc Bình Phạm, Thị Vân Anh Phạm, Thị Thu Hằng Đinh

Main Article Content

Abstract

Objectives: Investigate the protective effect of “Kien ty chi thong HV” remedy on rats with indomethacine- induced gastric-duodenal ulcer.


Methods and materials: The animals were divided into 5 groups: Group 1(control), group 2 (model), group 3 (misoprostol 50μg/kg), group 4 (KTHV 15g/kg) and group 5 (KTHV 30g/kg). All of rats were treated for 7 consecutive days. On day 7, rats were induced peptic-duodenal ulcers by oral indomethacine 40mg/kg. After 6 h, the number of rats with ulcer, ulcer index, the percentage of inhibition against ulceration, macroscopic and microscopic images were estimated.


Results: Indomethacine caused peptic ulcer in 100% of rats. KTHV at both doses reduced the number of ulcers and the ulcer indexes, increasing the percentage of inhibition against ulceration, decreasing the level of severity of gastric-duodenal ulcer in macroscopic and microscopic images when compared with model group.

Article Details

Keywords

“Kien ty chi thong HV” remedy, peptic-duodenal ulcer, indomethacine, rats.

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