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Study on toxicities of 10β-[(2'β-hydroxy-3'-imidazol) propyl] deoxo-artemisinin (32) in reproductive and developmental progresses of mice
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Objective: To test effects of 10β-[(2'β-hydroxy-3'-imidazol) propyl] deoxo-artemisinin (32) on mice’s reproductive and developmental processes.
Subjects and Methods: OECD guidelines were applied. Mice were divided into 7 groups consisting of 30 females and 10 males each. In which, the control group received the solvent, only females or males in 4 other groups were taken the testing samples (32), and both females and males of 2 remain groups were given those samples. Mice were given oral samples at a dose of 288 or 576 mg/kg/day × 7 consecutive days depending on individual group. Then, 3 females and a male were grafted in a cage. The compound (32)’s effects on reproductive and developmental processes of mice in 3 generations of P, F1 and F2 were monitored and evaluated by the Bateman technique.
Results: Conception rates, numbers of eggs nested, numbers of pups born, average weights of pups, numbers of days needed to raise pups to adulthood between the test and control groups differed insignificantly (p > 0.05). The pups born from generations P, F1 and F2 all grew and developed normally.
Conclusion: The compound (32) was not mutagenic in mice at oral dose regimens of 288 and 576 mg/kg/day × 7 consecutive days.
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Từ khóa
10β-[(2'β -hydroxy-3'-imidazol) propyl] deoxo-artemisinin, reproduction, development.
Tài liệu tham khảo
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