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Ngày xuất bản: 25/08/2024
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DOI: https://doi.org/10.60117/vjmap.v55i2.287
Số xuất bản
Tập 55 Số 02 (2024)
Chuyên mục
Bài nghiên cứu
Trích dẫn bài báo
Pham, T. P., Nguyen, T. T. M., Bui, H. A., Nguyen, P. N. M., & Trinh, V. L. (2024). Evaluating the sub-chronic toxicity of the BOGA -TN tablets in experimental animals. Tạp Chí Y Dược cổ truyền Việt Nam, 55(02). https://doi.org/10.60117/vjmap.v55i2.287

Evaluating the sub-chronic toxicity of the BOGA -TN tablets in experimental animals

Pham Thuy Phuong1,, Nguyen Thi Thu May1, Bui Hoang Anh1, Nguyen Pham Ngoc Mai2, Trinh Vu Lam1
1 Viet Nam University Of Traditional Medicine
2 Hanoi University of Science and Technology

Nội dung chính của bài viết

Tóm tắt

Objective: To assess the sub-chronic toxicity of Boga-TN tablets in experimental animals to determine the effects of the drug on the hematological and biochemical indices.


Subjects and Methods: Sub-chronic toxicity experiment was carried out in compliance with the guidance of the World Health Organization. Wistar rats (160 - 200g) of both genders, provided by the Laboratory Animal Center, Dan Phuong district, Hanoi were used


Results: The study was carried out in Wistar rats for 4 consecutive weeks by oral administration at the doses of 0.77 and 2.32g/kg/day. After treatment, no significant treatment-related abnormalities were observed at both doses of Boga-TN, compared to the control group, except for the white blood cells, with lower neutrophil but higher lymphocyte values observed in the treated animals. Histopathology assessment did not show any significant variation between control and treatment groups during the study period.


Conclusions: Boga-TN with a dose equivalent to the proposed clinical dose and 3 times the clinical dose did not cause any significant toxicity resulting in death, or produce any hematological, serum chemical alteration, and histo-pathological derangements. However, significant reductions in the levels of WBC, lymphocytes and increased levels of neutrophil in treated groups were detected after 4 weeks of treatment.

Chi tiết bài viết

Từ khóa

Sub-chronic toxicity, Boga-TN tablets, experimental animals.

Tài liệu tham khảo

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