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Effect of the remedy Xuong khop nam thang on strength, knee joint morphology on osteoarthritis model with monosodium iodoacetate
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Abstract
Objectives: To evaluate the effect of the remedy Xuong khop Nam Thang on weight bearing capacity of the knee joint in a model of osteoarthritis induced by monosodium iodoacetate (MIA).
Subjects and methods: 50 Wistar white rats, divided into 05 lots, 10 mice/lot: Physiological control group; 04 lots (Model/Treatment 1/Treatment 2/Reference lot) caused osteoarthritis by MIA, after 1 week of MIA injection to mice drinking distilled water/ the remedy Nam thang bones and joints dose 12,6 g/kg/day and 25,2 g/kg/day/indomethacin.
Results: The remedy Xuong khop Nam thang dose 12,6 g/kg/day and 25,2 g/kg/day had the effect of increasing the distribution of weight tolerance of the hind legs (p < 0.001 and p < 0.01) compared with the model lot; p < 0.001 compared to before drug use); Reduces inflammatory and degenerative knee joint damage on HE-stained knee histopathology, reduces the score of knee osteoarthritis histopathological damage (p < 0.05 compared to the model lot). These effects of the remedy Xuong khop Nam thang were comparable to those of indomethacin at a dose of 2mg/kg/day.
Conclusions: The remedy Xuong khop Nam thang have analgesic, anti-inflammatory and anti-degenerative effects on osteoarthritis models.
Keywords: Xuong khop Nam thang, knee osteoarthritis, rat.
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References
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