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Ngày xuất bản: 15/06/2023
Số lượt xem tóm tắt: 16
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DOI: https://doi.org/10.60117/vjmap.v50i3.221
Số xuất bản
Tập 50 Số 3 (2023)
Chuyên mục
Bài nghiên cứu
Trích dẫn bài báo
Doan, M. T., Ha, Q. P., Nguyen, H. N., Pham, H. T., Quach, T. Y., Lu, D. H. M., Tran, D. S., Pham, N. T., & Dang, T. L. P. (2023). Effects of Thuocnamtieuu: a Study in Mice Model of Induced Colorectal Tumors. Tạp Chí Y Dược cổ truyền Việt Nam, 50(3), 73-80. https://doi.org/10.60117/vjmap.v50i3.221

Effects of Thuocnamtieuu: a Study in Mice Model of Induced Colorectal Tumors

Doan Minh Thuy1, Ha Quang Phong1, Nguyen Hoang Ngan2, Pham Huyen Trang1, Quach Thi Yen1, Lu Doan Hoat Muoi1, Tran Dinh Sinh1, Pham Ngoc Tien1, Dang Thi Lan Phuong1,
1 1 Vietnam University of Traditional Medicine
2 Vietnam Military Medical University

Nội dung chính của bài viết

Tóm tắt

Objectives: The present study was undertaken to evaluate the effects of Thuocnamtieuu in AOM/ DSS-induced-colorectal tumors mice.


Subject and method: 48 six-week-old Swiss mice were randomly divided into 06 groups. Two doses of Thuocnamtieuu were administered via intragastric gavage to Swiss mouse with AOM/ DSS induced colorectal tumours. After 28 days treatment, all mice were sacrified. Assessment of the number and size of colorectal tumours, histopathological analysis were performed.


Results: The data have shown that Thuocnamtieuu has been effective in reducing significantly tumor volume (both benign and cancerous), but had not significantly decreased the number of tumors, reducing significantly the number of abnormal cells (cellular pleomorphism, Langerhang cells) in experimental colorectal cancer mice when compared to the control ones.


Conclusions: Thuocnamtieuu have the effect of reducing the colorectal tumors in a AOM/DSSinduced-colorectal tumors mice.

Chi tiết bài viết

Từ khóa

Colorectal tumour, Thuocnamtieuu, AOM/DSS.

Tài liệu tham khảo

1. International Agency for Research on Cancer. GLOBOCAN 2018, Online: https://www.uicc.org/ news/new-global-cancer-data-globocan-2018.
2. International Agency for Research on Cancer.
GLOBOCAN 2018, Online: http://gco.iarc.fr/today/ data/factsheets/populations/704-viet-nam-factsheets.pdf.
3. Cai. Q., Lin. J., Wei et al. Hedyotis diffusa Willd Inhibits Colorectal Cancer Growth in Vivo via Inhibition of STAT3 Signaling Pathway. International Journal of Molecular Sciences, 2012, 13(5), pp. 6117–6128.
4. Eun Young Seo and Woo Kyoung Kim. Red Ginseng Extract Reduced Metastasis of Colon Cancer Cells In Vitro and In Vivo, J Ginseng Res; 2011, 35(3), pp. 315–324.
5. Hu. H., Ahn et al. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int. J. Cancer, 2002, (102), pp. 250–253.
6. Na. Kun et al. Anticarcinogenic Effects of Water Extract of Sporoderm-Broken Spores of Ganoderma Lucidum on Colorectal Cancer in Vitro and in Vivo. International Journal of Oncology, 2017, 50.5, pp. 1541–1554.
7. Tseng A, Yang C-H, Chen C-H, et al. An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract. Oncology Reports, 2016, 35(2). pp. 659-668.
8. Ameet I. Thaker, Anisa Shaker, M. Suprada Rao, Matthew A. Ciorba. Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS). Journal of Visualized Experiments, 2012, 67, pp. 4100.
9. Phong. Ha Quang, Thuy Doan Minh, Ngan Nguyen Hoang. Perfecting colorectal cancer model on white mice. Journal of Traditional Vietnamese Medicine and Pharmacy, 2018, No. 02, pp.11-18.
10. Chun Seng Lee, Elizabeth J Ryan, Glen A Doherty. Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation. World J Gastroenterol, 2014 April 14; 20 (14), pp. 3751-3761.