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Date Published: 15/06/2023
Abstract Views: 35
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DOI: https://doi.org/10.60117/vjmap.v50i3.221
Issue
Vol. 50 No. 3 (2023)
Section
Research Articles
How to Cite
Doan, M. T., Ha, Q. P., Nguyen, H. N., Pham, H. T., Quach, T. Y., Lu, D. H. M., Tran, D. S., Pham, N. T., & Dang, T. L. P. (2023). Effects of Thuocnamtieuu: a Study in Mice Model of Induced Colorectal Tumors. Viet Nam Journal of Traditional Medicine and Pharmacy, 50(3), 73-80. https://doi.org/10.60117/vjmap.v50i3.221

Effects of Thuocnamtieuu: a Study in Mice Model of Induced Colorectal Tumors

Minh Thuy Doan, Quang Phong Ha, Hoang Ngan Nguyen, Huyen Trang Pham, Thi Yen Quach, Doan Hoat Muoi Lu, Dinh Sinh Tran, Ngoc Tien Pham, Thi Lan Phuong Dang

Main Article Content

Abstract

Objectives: The present study was undertaken to evaluate the effects of Thuocnamtieuu in AOM/ DSS-induced-colorectal tumors mice.


Subject and method: 48 six-week-old Swiss mice were randomly divided into 06 groups. Two doses of Thuocnamtieuu were administered via intragastric gavage to Swiss mouse with AOM/ DSS induced colorectal tumours. After 28 days treatment, all mice were sacrified. Assessment of the number and size of colorectal tumours, histopathological analysis were performed.


Results: The data have shown that Thuocnamtieuu has been effective in reducing significantly tumor volume (both benign and cancerous), but had not significantly decreased the number of tumors, reducing significantly the number of abnormal cells (cellular pleomorphism, Langerhang cells) in experimental colorectal cancer mice when compared to the control ones.


Conclusions: Thuocnamtieuu have the effect of reducing the colorectal tumors in a AOM/DSSinduced-colorectal tumors mice.

Article Details

Keywords

Colorectal tumour, Thuocnamtieuu, AOM/DSS.

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