Article Sidebar
Views PDF: 128
Study of semi-permanent toxicity of Actiso extract on experiment
Main Article Content
Abstract
Objectives: The research evaluated the sub-chronic toxicities of artichoke (Cynara scolymus L.) liquid extract through oral administration in experimental animals.
Methods: The sub-chronic toxicity study was conducted by the recommendation of WHO in rats with oral doses of 0.2 g/kg/day and 1.0 g/kg/day in 4 consecutive weeks. As a result, oral administration of Cynara scolymus L. liquid extract at the doses of 0.2 g/kg/day and 1.0 g/kg/day had no effect on general condition, body weight, hepato-renal functions and histopathological structures of liver and kidney. In conclusion, Cynara scolymus L. extract does not appear to produce sub-chronic toxicities in experimental animals.
Article Details
Keywords
Artichoke (Cynara scolymus L.), sub-chronic toxicity, experimental animals.
References
2. Viện Dược liệu. Cây thuốc và động vật làm thuốc, Nhà xuất bản Khoa học và Kỹ thuật, Hà Nội, 2007.
3. Ben Salem M, Affes H, Ksouda K, et al. Pharmacological studies of artichoke leaf extract and their health benefits. Plant Foods Hum Nutr. 2015;70:441–53.
4. El-Boshy M, Ashshi A, Gaith M, et al. Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toXicity-induced oXidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int. 2017;24:12372–383.
5. World Health Organization. Working group on the safety and efficacy of herbal medicine, Report of regional office for the western pacific of the World Health Organization. 2000.
6. Nguyễn Thế Khánh, Phạm Tử Dương. Xét nghiệm sử dụng trong lâm sàng, Nhà xuất bản Y học. 2001.
7. Vũ Đình Vinh. Hướng dẫn sử dụng các xét nghiệm sinh hoá, Nhà xuất bản Y học. 2001,115-287.