Nghiên cứu đánh giá tác dụng chống viêm, giảm ho, long đờm của cao cát sâm

Abstract

Objectives: To evaluate of the anti-inflammatory, cough relief and expectorant effects of Millettia speciosa extraction in Swiss mice and Wistar rats.

Subjects and methods: Testing the anti-inflammatory effect of Millettia speciosa extraction on mice using the carageenin method of causing mice paw edema by Winter C.A. Evaluate the cough suppressant effect using the N.A.Roe method on mice. Evaluate the expectorant effect on mice using the method of Yu P.

Results: Millettia speciosa extraction at doses of 11.2g and 5.6g extraction/kg had statistically significant effects on reducing paw inflammation compared to the control group (p < 0.01 and < 0.05). Millettia speciosa extraction at both doses prolonged the potential duration of cough in ammonia-induced white mice, reduce the number of coughs at 10 minutes, the reductions were 9.83 and 15.16% respectively. Millettia speciosa extraction tended to change the optical density at 265nm and slightly increase the optical absorption, so Millettia speciosa extraction had expectorant effect, but the effect was still weak.

Conclusions: Millettia speciosa extraction at doses of 11.2g and 5.6g extract/kg weight had statistically significant effects on reducing paw inflammation compared, had the effect of prolonging the duration of cough in white mice caused by ammonia and directly inhibiting coughs at 10 study time points was almost equivalent to that of codeine at a dose of 20mg/kg/day. Millettia speciosa extraction had expectorant effect, but the effect is still weak.