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Đánh giá ảnh hưởng của viên nang ĐTB lên các chỉ số sinh hóa và mô bệnh học của động vật thực nghiệm
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Abstract
Objectives: To study the influence of ĐTB capsules on biochemical indicators and histopathological images in experimental animals.
Subjects and methods: Experimental study on Wistar, following the Ministry of Health guidelines. White rats were given oral administration of ĐTB at a dose of 280mg/kg/day and a dose of 840mg/kg/day for 90 consecutive days.
Results: The rats remained in good health, gaining weight well and evenly throughout the study. There was no change in the blood biochemical indicators of liver and kidney function (AST, ALT, plasma albumin, total cholesterol, total bilirubin, and creatinine) compared with the control group. Importantly, there was no histopathological damage to the liver, spleen, or kidney.
Conclusions: The use of ĐTB capsules for a period of 90 days did not yield any statistically significant differences compared with the control group in blood biochemical indicators, or histopathological images of liver, spleen, and kidney.
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Keywords
ĐTB capsules, blood biochemistry, histopathological images.
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