Tác dụng chống viêm, giảm đau của Hoàng bá nam trên thực nghiệm

Abstract

Objective: To evaluate the anti-inflammatory and analgesic effects of Cortex oroxyli in experimental animals.

Subjects and methods: An experimental study was conducted using the arthritis model induced by Freund adjuvant in white rats, the hot plate pain relief model, and the acetic acid-induced abdominal pain model.

Results: Cortex oroxyli at a dose of 1.68 g/kg/24h and 3.36g/kg/24h had anti-arthritis effects by reducing the diameter of the rat ankle joint and improving the anatomical images of the inflamed rat ankle joint. Cortex oroxyli at a dose of 2.88 g/kg/24h and 8.64g/kg/24h had analgesic effect on hot plate model by increasing respectively 21.4% and 34.3% time to response to heat-induced pain in rats (p<0.05 and p<0.01); had analgesic effect on the acetic acid-induced abdominal pain model by increasing the onset time of colic, reducing the number of episodes of cramping pain compared with the control group.

Conclusions: Cortex oroxyli has analgesic and anti-inflammatory effects in experiments.