Đánh giá tác dụng điều chỉnh rối loạn lipid máu của cao khô me rừng trên chuột cống trắng

Abstract

Objectives: Evaluate the dyslipidemia adjusting effects of Phyllanthus emblica L. dry extrasct in Wistar rat.

Subject and methods: The experiment was conducted using the adjusted model of Nassiri et al. (2009). Wistar rats were induced dyslipidemia by giving orally the mixture of cholesterol oil (10 ml/kg/24h dose). Rats were randomly assigned to 5 groups, 10 each (n = 10). Group 1 was given distilled water 10 ml/kg; Group 2: cholesterol oil and distilled water 10 ml/kg after 02 hours, respectively; Group 3: cholesterol oil and reagent dose 450 mg/kg after 2 hours; Group 4 drank cholesterol oil + reagent 900 mg/kg after 2 hours; Group 5 drank cholesterol oil + atorvastatin 10 mg/kg after 2 hours. Evaluation indices: triglycerides (TG), total cholesterol, HDL-C, LDL-C, before and after 14-28 days.  

Results: All groups that were induced lipid disorder with mixture of cholesterol oil 10 ml/kg/24h increased TG, total cholesterol, LDL-C. Groups 3, 4, 5 showed the effect of reducing TG, total cholesterol, LDL-C; increased HDL-C in blood compared with group 2 at 14 and 28 days after the treatment, the change was statistically significant with p < 0.05.                      

Conclusions: Phyllanthus emblica L. dry extrasct at the dose of 450 mg/kg/24h and 900mg/kg/24h showed good effect in the treatment of dyslipidemia, equivalent to Atorvastatin 10mg/kg/24h.