Nghiên cứu ảnh hưởng của viên nén Boga TN lên chức phận tạo máu của chuột cống trắng

Abstract

Objectives: To assess the hematopoietic functions of Wistar rats given BOGA TN tablets orally.

Subjects and methods: Sub - chronic toxicity experiment was carried out in compliance with guidance of World Health Organization. Rats were randomly divided into 3 groups of 10 Wistar rats each.

Results: BOGA TN tablet at a regimen dose of 0.77 g/kg/day x 28 consecutive days (equivalent to the expected clinical dose in human) and 2.32 g/kg/day did not affect the red blood cells and platelet counts, hemoglobin, hematocrit and mean corpuscular volume, but decreased the white blood cell count, statistically significant compared with those of the  control group and between before-after the experiment (p<0.001; p<0.01), increased the percentage of neutrophils  and decreased the portion of lymphocytes  statistically significant  compared with that of the control group and before the study (p<0.001).

Conclusions: Boga TN at a dose of 0.77g/kg/day (equivalent to the expected clinical dose) and 2.31g/kg/day, orally given continuously for 4 weeks did not change the  hematopoietic function indices, except lower neutrophil but higher lymphocyte values were observed in Wistar rats.