Article Sidebar
Views PDF: 9
Research on anti-gastric ulcer effects of [murdannia bracteata (c.b.clarke) j.k.morton ex d.y.hong] extract in experiment
Main Article Content
Abstract
Objective: To evaluate the experimental anti-gastric ulcer effect of ethyl acetate fractionated extract of Herba Murdanniae bracteatae (MNC1).
Subjects and methods: Research the anti-gastric ulcer effect of MNC1 on the gastric ulcer model caused by indomethacin in Wistar white rats.
Results: The results showed that MNC1 protected mucosa on the gastric ulcer model caused by indomethacin in white rats. It insignificantly reduced the rate of rats with gastric ulcers compared to that of the model group (p>0.05). Moreover, it statistically significantly reduced the ulcer indexes and ulcer inhibition rate of rats (p<0.05).
Conclusions: Ethyl acetate fractionated extract from Herba Murdanniae bracteatae at a regimen dose of 180 mg/kg/day for 10 consecutive days has the remarkable effect of inhibiting ulcers by 23.23% compared to that of the model group (p<0.05). In addition, Herba Murdanniae bracteatae extracts also reduce macroscopic and microscopic damages to rats’ stomach.
Article Details
Keywords
Murdannia bracteata, anti-gastric ulcer effects, Wistar rat.
References
2. Chanda S, Baravalia Y, et al. Ethanol/HCl induced ulcer in rats and its antimicrobial potency. Asian Pacific Journal of Tropical Medicine, 2011, 673, pp.679.
3. Palle S, Kanakalatha A, et al. Gastroprotective and antiulcer effects of Celastrus paniculatus seed oil against several gastric ulcer models in rats. Journal of dietary supplements, 2018,15(4), pp.373-385.
4. Pellegrini MOO, Faden RB, et al. Taxonomic revision of Neotropical Murdannia Royle (Commelinaceae). PhytoKeys, 2016, 74, pp.35.
5. Wang GJ, Chen SM, et al. Selective inducible nitric oxide synthase suppression by new bracteanolides from Murdannia bracteate. Journal of Ethnopharmacology, 2007, 112(2), pp.221- 227.
6. Anurag Mishra, Sandeep Arora, et al. Effect of Feronia elephantum (Corr) Fruit Pulp Extract on Indomethacin-induced Gastric Ulcer in Albino Rats. Tropical Journal of Pharmaceutical Research, 2009, 8(6), pp.509-514.
7. Raish M, Shahid M, et al. Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role. Front Pharmacol, 2021,12, pp.622815.
8. Simões S, Lopes R, et al. Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation. Animal Model Exp Med, 2019, 2(2), pp.121-126.
9. Tan B, Chiranthanut N, et al. Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats. Heliyon, 2023, 9(8), e19297.
10. Toktay E, Yayla M, et al. The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin‐induced stomach ulcer in rats. Journal of Food Biochemistry, 2022, 46(9), e14274.
11. Watkinson G, Hopkins A, et al. The therapeutic efficacy of misoprostol in peptic ulcer disease. Postgraduate Medical Journal, 1988, 64, pp.60-77.