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Date Published: 25/08/2024
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DOI: https://doi.org/10.60117/vjmap.v55i2.278
Issue
Vol. 55 No. 02 (2024)
Section
Research Articles
How to Cite
Nguyễn, D. H., Phạm, B. T., & Nguyễn, T. N. (2024). Researching the acute toxicity and the effects on interleukin-6 serum concentrations of the TLT-BCA pill in experiment. Viet Nam Journal of Traditional Medicine and Pharmacy, 55(02). https://doi.org/10.60117/vjmap.v55i2.278

Researching the acute toxicity and the effects on interleukin-6 serum concentrations of the TLT-BCA pill in experiment

Duy Hoàn Nguyễn, Bá Tuyến Phạm, Trường Nam Nguyễn

Main Article Content

Abstract

Objective: To research the acute toxicity and the effects on Interleukin-6 serum concentrations of the TLT-BCA pill in prostate hyperplasia model.


Subjects and methods: Acute toxicity evaluation: Swiss rats were orally given the solution of TLT-BCA pill with different doses to evaluate toxic dose and LD50 using Litchfield - Wilcoxon method. Effects on Interleukin-6 evaluation: the prostate hyperplasia model in 06 pathological groups were induced by subcutaneously injected testosterone propionate (TP) (0.003g/kg/24h) and the blank group was subcutaneously injected by vegetable oil in 28 consercutive days. Afterward, 04 trial groups were respectively given TLT-BCA (0.7g/kg/day and 2.1g/kg/day), Dutasteride (25µg/kg/24h) and Tamsulosin 80µg/kg/24h; physiological and pathological groups were respectively given saline orally in 28 consecutive days. Levels of Interleukin-6 in serum and prostate tissues were collected and compared among 6 groups at the 29th day.


Results: The TLT-BCA pill did not show acute toxicity signs and the LD50 was not identified in the highest oral dose of 30.0g/kg/24h. The TLT-BCA pill at the doses of 700mg/kg/24h and 2100mg/kg/24h decreased Interleukin-6 level in serum and prostate issues with p<0.01 and p<0.05 respectively.


Conclusions: The TLT-BCA pill did not cause acute toxicity and LD50 was not identified. The TLT-BCA pill at the doses of 700mg/kg/24h and 2100mg/kg/24h decreased Interleukin-6 level in serum and prostate issues of laboratory rats.

Article Details

Keywords

Acute toxicity, Prostate hyperplasia, Interleukin-6, Wistar rats

References

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