Đánh giá tác dụng của viên nang cứng TRIHV trên mô hình gây trĩ thực nghiệm

Abstract

Objectives: To evaluate the effect of TRIHV hard capsules on experimental hemorrhoidal induced model.

Subjects and methods: White rats were experimentally modeled for hemorrhoids with a Croton oil mixture. The effect of TRIHV hard capsules was evaluated at doses of 1.08g/kg/day and 3.24g/kg/day with research criteria: Macroscopic, microscopic rectal assessment, evaluation of hepatorenal cell destruction.

Results: TRIHV hard capsules at a dose of 3.24g/kg/day have the effect of reducing anal-rectal weight, hasten the recovery of rectal epithelium, reducing leukocyte infiltration and congestion compared to the model batch. TRIHV hard capsules at doses of 1.08 g/kg/day tended to act on an experimental model of white hemorrhoid-induced rats with a croton oil mixture. TRIHV at doses of 1.08 g/kg/day and doses of 3.24 g/kg/day did not alter AST, ALT and urea and creatinine levels in the blood of white rats causing experimental hemorrhoid models. Conclusions: TRIHV hard capsules have the effect of reducing rectal inflammation and safety, do not affect liver and kidney function, white rats are experimentally induced hemorrhoids.

Key word: TRIHV, Croton, experimental, White Rat.