Nghiên cứu độc tính đường uống và tác dụng chống loét dạ dày của viên nang mộc tỳ vị trên chuột cống trắng

Abstract

Objective: Assess the potential effects of Moc Ty Vi capsules on rats by examining sub-chronic oral toxicity and their ability to prevent gastric ulcers.

Subjects and methods: Assessment of sub-chronic toxicity was conducted following the guidelines provided by the Ministry of Health  for pre-clinical drug testing. The aim was to evaluate the effectiveness of Moc Ty Vi capsules in treating gastric ulcers using an indomethacin-induced ulcer model on Wistar white rats.

Results: The experiment showed that there were no statistically significant differences in the general condition of the mice, as well as in the hematological, biochemical, and histological indices of the liver and kidneys between the control group and the two drug treatment groups (p > 0.05). At a lower dosage of 252mg/kg/day, the wood spleen capsules demonstrate a greater efficacy in reducing ulcer index, ulcer inhibition percentage, and microscopic gastric damage compared to the higher dosage of 756mg/kg/day.

Conclusion: The safety of Moc Ty Vi hard capsules has been demonstrated in studies evaluating semi-chronic toxicity on rats, regarding the dose and duration of use. When administered orally for 7 days, at a dose of 252mg/kg/day, Moc Ty Vi demonstrates a superior anti-gastric ulcer effect compared to the higher dose of 756mg/kg/day.