Nghiên cứu độc tính cấp và ảnh hưởng lên một số chỉ số huyết học của viên nang cứng mỡ máu Tâm Bình trên thực nghiệm

Abstract

Objectives: To evaluate the acute toxicity and the effects on hematopoietic, liver and kidney functions of Mo Mau Tam Binh hard capsules in experiment.

Subjects and methods: An experimental study with a controlled group was conducted. Assessing acute toxicity and LD₅₀ determination on Swiss white mice - following WHO guidelines and Gerhard Vogel H (2016). Subchronic toxicity study: orally on white rats following WHO guidelines. 

Results: The LD₅₀ in mice of Mo Mau Tam Binh hard capsules taken orally has not been determined. No signs of acute toxicity at a dose of 44 capsules/kg/day. Mo Mau Tam Binh hard capsules when taken orally for 4 consecutive weeks with 2 dosage levels: 420 mg/kg/day and 1260 mg/kg/day had no negative effects on the number of platelets, red blood cells, white blood cells, hematocrit, mean corpuscular volume and hemoglobin of mice.

Conclusions: Mo Mau Tam Binh hard capsules at a dose 30.6 times higher than the expected human dose showed no acute toxicity in mice orally. Mo Mau Tam Binh hard capsules when taken orally for 4 consecutive weeks with 2 dosage levels of 420 mg/kg/day and 1260 mg/kg/day did not affects the hematopoietic, liver and kidney functions of mice.