Nghiên cứu độc tính bán trường diễn và tác dụng điều trị trào ngược dạ dày thực quản của Bột cốm kiện tỳ chỉ thống - HV trên thực nghiệm

Abstract

Objective: To investigates the subchronic toxicity and treatment of gastroesophageal reflux using Kien ty chi thong-HV (KTHV) granules in experimental.

          Subjects and methods: Experimental animal testing was conducted according to WHO guidelines and Koji Takeuchi's model.

          Results: The KTHV 1.8 g/kg/day (equivalent to the expected clinical dose) and 5.4 g/kg/day, administered continuously for 4 weeks, did not cause subchronic toxicity in white rats. In the gastroesophageal reflux model, the KTHV 1.8 g/kg/day increased the pH of gastric juice by 3.33 ± 1.07, while the 3.6 g/kg/day increased it by 3.22 ± 1.05. The total acidity at the KTHV 1.8 g/kg/day decreased by 36.05 ± 9.90, KTHV 3.6 g/kg/day decreased by 35.96 ± 10.21 (p < 0.01 compared to the model group). KTHV also tended to reduce gastric juice volume, free acidity, and the average ulcer area, as well as the esophageal index, compared to the model group. The ulcer reduction rates were 1.80% and 22.72%, respectively.

          Conclusions: Kien ty chi thong-HV does not cause subchronic toxicity in white rats and effectively increases gastric pH and reduces total acidity, with statistical significance compared to the model group at both dose levels (p<0.01). It also tends to reduce gastric juice volume, free acidity, average ulcer area, and the esophageal index compared to the model group.