Investigating the therapeutic mechanisms of qiju-dihuang wan in diabetic retinopathy by using network pharmacology and molecular docking
Main Article Content
Abstract
Objective: To explore the molecular mechanism of the drug QiJu-DiHuang Wan (QJDHW) in the adjunctive treatment of Diabetic Retinopathy (DR).
Subjects and methods: Compounds from QJDHW and DR treatment targets were analyzed from open-access databases. A protein-protein interaction and a compound- target network were constructed using STRING and Cytoscape. Relevant signaling pathways were identified through GO and KEGG enrichment analysis using DAVIDs. Molecular interactions were evaluated using Autodock Vina and BIOVIA Discovery Studio 2021.
Results: The study identified 10 bioactive compounds from QJDHW interacting with 10 key target proteins, which are involved in crucial signaling pathways for DR treatment. Molecular docking showed strong binding affinities between the compounds and their targets.
Conclusions: This research provides a theoretical basis for the effects of QJDHW in the adjunctive treatment of DR and identified and identifies potential therapeutic targets, thereby promoting the development of traditional medicine formulas for DR treatment.
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References
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