Tác dụng chống viêm và giảm đau của bài thuốc Phong thấp thang trên thực nghiệm

Abstract

Objective: To evaluate the anti-inflammatory and analgesic effects of the remedy Phong thap thang in experiments.

Subjects and methods: An experimental study was conducted on 4 models: evaluating the acute anti-inflammatory effect on Carrageenan-induced mice paw edema model, the chronic anti-inflammatory effect on the FCA-induced mice paw edema model, the central analgesic effect using the tail immersion model and the peripheral analgesic effect using the acetic acid intraperitoneal injection model.

 Results: The remedy Phong Thap thang at a dose of 30.72 g/kg/day reduced the level of mice paw edema in the anti-inflammatory model using Carageenan by 74.81% and FCA by 103%; the pain response time in the tail immersion model was 60 minutes and reduced the number of colic pains in the acetic acid intraperitoneal injection model for up to 20 minutes. This dose was equivalent to the effect of Diclofenac (p < 0.05) in anti-inflammatory models and less effective than Codein (p<0.001) in pain models. The dose of 30.72 g/kg/day was the most optimal dose among the three dose levels of 15.36; 30.72; 7.68 g/kg/day.

Conclusion: The remedy Phong thap thang has anti-inflammatory and analgesic effects on experimental mice.