Nghiên cứu hiệu quả điều trị và tính an toàn của Hợp phương tứ quân tử thang và ô bối tán ở người bệnh viêm dạ dày tá tràng HP âm tính

Abstract

Objective: To evaluate the effectiveness and adverse drug reactions of the combination of Tu quan tu thang and O boi tan in patients with HP-negative gastroduodenitis.

Subjects and methods: A total of 90 patients with HP-negative gastroduodenitis were divided into 2 groups of 45 people each. Patients in the study group took a combined decoction of Tu quan tu thang and O boi tan at a dosage regimen of 45 g/300 ml/day, divided into 2 times, for 28 consecutive days while the control group took 40 mg pantoprazole tablets/time/day x 28 consecutive days. The effectiveness of the test sample and control drug in improving patients' gastroduodenitis and their adverse effects (if any) in both groups were evaluated. The study indexes included VAS pain scores, symptoms of the disease, total symptom scores and paraclinical indices (hematology, AST, ALT, urea, creatinine).

Results: Patients in the experimental group had a statistically significant higher treatment effect (80%) than that of the control group (31.1%), p<0.05. No adverse drug reactions were detected during 28-day treatment periods. Patients' hematological and biochemical indices did not change statistically significantly.

Conclusion: The combined decoction of Tu quan tu thang and O boi tan was highly effective in treating patients with HP-negative gastroduodenitis and did not cause unwanted effects during the 28-day treatment period.