Ứng dụng công nghệ niosome trong bào chế sản phẩm chăm sóc da chứa hợp chất resveratrol

Abstract

Objectives: To prepare a niosome drug carrier system containing 0,01%-0,1% resveratrol at a scale of 50 ml/batch and to prepare a skin care product (gel/serum) containing niosome with a resveratrol content of 0,01%-0,1% at a scale of 50 g/batch.

Subject and methods: The niosome system was prepared by ethanol injection method. Particle size and particle size distribution were evaluated by laser scattering. Skin permeability was tested Hanson Research membrane release test system. Quantification was performed by HPLC.

Results: The niosome system was prepared with the following ingredients: resveratrol, span 60, cholesterol. The niosome gel formula include: niosome suspension, glycerin, sepimax zen, nipagin. The resveratrol content in the prepared gel is 98,27% compared to the theory. The ability to release the drug and the amount of drug retained on the skin after 24 hours, the niosome gel sample released the drug faster than the suspension gel.

Conclusions: The formula, preparation process and evaluation of some properties of niosome drug carrier system and niosome-containing gel with resveratrol content of 0,01%-0,1% have been established.