Đánh giá tác dụng giảm đau của viên nang An Dạ trên thực nghiệm

Abstract

Objective: To evaluate the analgesic effect of An Da capsules in experiments.

Subjects and methods: The analgesic effect of An Da capsules was studied using two methods: Hot plate and needle prick on Swiss white mice.

Results: An Da capsules administered at doses of 528 mg/kg/day and 1056 mg/kg/day for 7 days increased pain reflex force and pain response time compared to pre-treatment levels; however, these changes were not statistically significant when compared to the blank control group. At a dose of 528 mg/kg/day for 7 days, An Da capsules increased the response time to temperature compared to both pre-treatment and the blank control group, but this difference was not statistically significant. In contrast, the 1056 mg/kg/day dose for 7 days significantly increased the response time to temperature compared to both pre-treatment and the blank control group.

Conclusions: An Da capsules administered orally at a dose of 1056 mg/kg/day for 7 days in white mice showed an analgesic effect in the hot plate test, but not in the needle prick test. At a lower dose of 528 mg/kg/day, An Da capsules did not have analgesic effects in either the hot plate or needle prick test.