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The results of acute and sub-chronic toxicity of Hoai Ky LC powder in experiments
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Abstract
Objective: To evaluate the acute and sub-chronic toxicity of Hoai ky LC powder in experiments.
Subjects and methods: An experimental research was conducted on Wistar rats and Swiss mice using Litchfield – Wilcoxon method, WHO and Ministry of Health guidelines. Hoai ky LC powder was produced at Lao Cai Traditional Medicine Hospital.
Results: Hoai ky LC powder did not show any acute toxicity at a dose of 31.25 g/kg/day on Swiss mice. The LD50 of Hoai ky LC powder taken orally has not been determined on Swiss mice. Hoai ky LC powder when administered orally for 4 consecutive weeks on Wistar rats at doses of 6g/kg/day and 12g/kg/day did not affect the general condition, hematological indices, liver and kidney function and microscopic structure of liver and kidney of Wistar rats.
Conclusion: Hoai ky LC powder is safe at the clinical dose of 50g/day.
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Keywords
Từ khóa: Hoài kỳ LC tán, độc tính cấp, bán trường diễn.
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