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Analyzing the use of quinolone antibiotics at Kien An Hospital, Hai Phong, Vietnam in 2024
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Abstract
Objectives: To describe patient demographics, infection types, clinical parameters, and to assess quinolone regimens, dosing, routes, duration, and IV-PO conversion rates.
Subject and methods: Only select medical records of inpatients ≥16 years old, with at least one use of quinolone; A systematic random sample of 384 inpatient records with quinolone therapy (January–December 2024) was analyzed. Data on demographics, diagnoses, renal function, quinolone regimens, dosage, administration route, treatment duration, and IV-PO switches were collected. Descriptive and inferential statistics were applied (α=0.05).
Results: Mean age was 53.6±10.6 years; 60.2% male. Respiratory (35%), urinary (25%), and skin/soft tissue (15%) infections predominated. Levofloxacin (52%) and ciprofloxacin (38%) were most used; 65% received combination therapy. Mean duration was 7.5±2.1 days; 5.8% of eligible patients switched IV-PO. Major non-switch reasons included unstable condition (19.6%) and deep-seated infections (21.6%).
Conclusions: Quinolone use is extensive with low IV-PO switch adherence. Stewardship interventions and clear protocols are needed to optimize therapy.
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Keywords
Keywords: Quinolone, antibiotic utilization, IV-to-oral switch, antimicrobial stewardship, hospital pharmacy.
References
2. Parker, A. M. et al. Outpatient Antibiogram and Predictors of Ciprofloxacin Resistance in Primary Care. Open Forum Infectious Diseases, 2020, 20(20 Suppl 1), 3177.
3. Nguyen, H. T. et al. Antibiotic Use in Public Hospitals in Vietnam between 2018 and 2022: A Procurement Based Consumption Analysis. Infection and Drug Resistance, 2023, 16, pp.1123–1132.
4. Morales Torres, M. L. et al. Drug Utilization Evaluation of Ciprofloxacin Use and Adverse Effects in a Tertiary Care Setting. Journal of Pharmacy Practice, 2023, 36(4), pp.507–516.
5. Banan M. Aiesh, Ahd Zuhour, Malak Abu Omar, Mays Haj Hamad, Adham Abutaha, Samah W. Al Jabi, Ali Sabateen & Sa’ed H. Zyoud. Patterns of fluoroquinolone utilization and resistance in a tertiary care hospital: a retrospective cross sectional analysis study from a developing country. BMC Infectious Diseases, 2024, 24(1), pp.856.
6. Gupta, N. et al. Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram Negative Bacteremia. Clinical Infectious Diseases, 2023, 76(2), pp.344-352.
7. Ahmer, O. et al. Role of Efflux Pumps in the In Vitro Development of Ciprofloxacin Resistance in Listeria monocytogenes. Frontiers in Microbiology, 2018, 9, 2350.