Thực trạng sử dụng thuốc và xây dựng danh mục tương tác thuốc – bệnh chống chỉ định của nhóm thuốc tim mạch và đái tháo đường trong điều trị ngoại trú tại Bệnh viện Châm cứu Trung ương năm 2024

Abstract

Objective: To survey  the current use of outpatient medications; To develop a list of drug-disease contraindications (CI) for cardiovascular (CV) and diabetes medications (DM) in outpatient treatment at the National Hospital of Acupuncture in 2024.

Subjects and methods: A cross-sectional descriptive study was conducted, involving the collection of outpatient medication data,  literature review, and expert consensus.

Results: Outpatient medications comprised 99 active ingredients across 16 groups. CV drugs accounted for 20.20% of all medications. Within the DM group, oral antidiabetic agents represented 57.14%, while insulin accounted for 42.86%. Oral administration was the predominant route (77.78%). The proportion of generic versus originator drugs was 61.54% and 38.46%, respectively. Imported drugs constituted 60.00% of all medications, while single-ingredient formulations accounted for 76.77%. The mean patient age was 70.31 ± 8.92 years, with females comprising 63.52% of the cohort. Notably, 27.89% of patients had one comorbid condition. The average number of medications per prescription was 2.80 ± 1.52, and all prescriptions (100%) included complete usage instructions. A total of 78 contraindicated drug–disease interaction pairs were identified, including 63 pairs related to CV drugs and 15 pairs related to DM drugs.

Conclusion: Outpatient drug utilization was dominated by CV medications, with a predominance of generic and imported drugs. The study population consisted mainly of older adults, with a higher proportion of females, and an average of 2.80 medications per prescription. A total of 78 contraindicated drug–disease interaction pairs were identified and compiled into a reference list.