Acute toxicity, analgesic and anti-inflammatory effects of soursop leaf ethanol extract (Paramignya trimera Oliv.) in vivo

Abstract

The study showed that ethanol extract from leaves of Paramignya trimera Oliv. had acute anti-inflammatory effects in carrageenan-induced paw edema in mice after carrageenan and chronic anti-inflammatory effects in Freund's complete adjuvant (FCA)-induced paw edema in mice after FCA injection at dose of 0.2, 0.4 and 1g/ kg/bodyweight. At dose of 0.2, 0.4 and 1g/kg/bodyweight, the extract also showed analgesic effects in the central nervous system on model Tail immersion, analgesic effects in peripheral nervous system on writhing test in mice.