Article Sidebar

PDF
Date Published: 24/03/2023
Abstract Views: 476
Views PDF: 378
DOI: https://doi.org/10.60117/vjmap.v47i1.9
Issue
Vol. 47 No. 1 (2023)
Section
Research Articles
How to Cite
Nguyen, T. A. N., & Nguyen, T. C. (2023). The analgesic and anti-inflammatory effects of soursop leaf ethanol extract of Gnetum montanum Markgr. in vivo. Viet Nam Journal of Traditional Medicine and Pharmacy, 47(1), 44-51. https://doi.org/10.60117/vjmap.v47i1.9

The analgesic and anti-inflammatory effects of soursop leaf ethanol extract of Gnetum montanum Markgr. in vivo

Thi Anh Nguyet Nguyen, Tien Chung Nguyen

Main Article Content

Abstract

This study was conducted to investigate evaluate the anti-inflammatory and analgesic effects of Gnetum montanum Markgr. extract. Methods: the anti-inflammatory effect was studied in two models of carragenin-in- duced paw edema and FCA-induced edema; the analgesic effect was studied on the model of colic pain and the Tail-immersion method. Results: In addition, the study also showed that at all 3 levels of tested doses, 150mg/kg, 250mg/kg and 500mg/kg Gnetum montanum Markgr extract exhibited acute and chronic anti-inflammatory effects, central analgesic and anti-inflammatory effects peripheral in experimental animals.

Article Details

Keywords

Gnetum montanum Markgr., pain relief, anti-inflammatory

References

1. Đỗ Tất Lợi (2019), Những Cây Thuốc Và Vị Thuốc Việt Nam, NXB Hồng Đức, Hà Nội, tr.662.
2. Võ Văn Chi (2000), Cây thuốc trị bệnh thông dụng, Nhà xuất bản Thanh Hoá, tr.136 – 137
3. Vũ Thị Lan Phương (2019), Nghiên cứu thành phần hoá học của cây gắm (Gnetum Montanum Markgr), Tạp chí khoa học số 34/2019, tr.45.
4. Đặng Thị Như Hoa (2011), “Đánh giá tính an toàn và tác dụng trên bệnh Gout của cao dây gắm”.
5. Traore A, Sylvin Ouedraogo, Adama Kabore, Hamidou H Tamboura and I Pierre Guissou (2014), The acute toxicity in mice and the in vitro anthelminthic effects on Haemonchus contortus of the extracts from three plants (Cassia ieberiana, Guiera senegalensis and Sapium grahamii) used in traditional medicine in Burkina Faso. Annals of Biological Research, 5 (2):41-46
6. McCarson, K.E. (2015), Models of inflammation: Carrageenan- or complete freund’s adjuvant (CFA)–induced edema and hypersensitivity in the rat. Curr. Protoc. Pharmacol. 70:5.4.1-5.4.9.
7. Đỗ Trung Đàm (2017), Thuốc giảm đau chống viêm và các phương pháp nghiên cứu tác dụng dược lý, NXB Y học, Hà Nội, tr. 17-246
8. C.A. Winter, et al.(1962), “Carrageenin induced edema in hind paw of the rat as an assay for anti inflammatory drug”, Proc. exp. Biol. N.J., 111, pp.544-574.