Nghiên cứu tác dụng hạ huyết áp, giảm tổn thương cầu thận của viên nang Bảo thận khang trên chuột cống trắng

Abstract

Objectives: To evaluate the effect of Bao Than Khang capsules on the model of hypertension with glomerular damage by L-NAME in Wistar rats.

Subjects and methods: Rats were given L-NAME at a dose of 10mg/kg/day and given Bao Than Khang for eight consecutive weeks. The evaluation included 24-hour urine albumin, blood urea, and creatinine, blood pressure measurement by a noninvasive rat tail blood pressure measure, and weight and histopathology of the rat kidney.

Results: The administration of Bao Than Khang capsules at 700 mg/kg/day and 1400 mg/kg/day significantly reduced blood pressure, blood urea, creatinine, and 24-hour urinary albumin. Furthermore, it improved renal histopathology, with reduced glomerular size, decreased proliferation of endothelial and intercapillary cells, and decreased glomerular and interstitial fibrosis compared with the pathology group.

Conclusions: The administration of Bao Than Khang capsules at 700 mg/kg/day and 1400 mg/kg/day was found to significantly lower blood pressure and reduce glomerular damage in Wistar rats.